Cholinergic drugs are medications that inhibit, enhance, or mimic the action of the neurotransmitter acetylcholine, which is the primary transmitter of nerve impulses within the parasympathetic nervous system. This pharmacology lecture covers topics such as mechanism of action of cholinergic agonists, cholinergic receptors; muscarinic & nicotinic, direct-acting cholinergic agonists, indirect-acting cholinergic agonists (reversible & irreversible), cholinergic toxicity & adverse effects. Cholinergic drugs mentioned include: Acetylcholine, Carbachol, Pilocarpine, Bethanechol, Edrophonium, Physostigmine, Neostigmine, Pyridostigmine, Donepezil, Rivastigmine, Galantamine, Echothiophate.

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  1. i had a doubt ….during eye surgery y would u opt for a cholinergic drug which would cause miosis…shouldn't one opt for an anticholinergic drug causing mydriasis

  2. When u studying hard then ur parents enter ur room only when the adv appear at this moment u will now how unlucky person You are

  3. At 1:19 you talk about the binding to presynaptic receptors , and that this inhibits further release of ACh. From my understanding, this is the effect of presynaptic muscarinergic receptors, but with little clinical effect. The binding of ACh to the nicotinergic receptor is a positive feedback mechanism, and is far more effective than the muscarinergic, resulting in the different effect of depolarizing and non-depolarizing neuromuscular blocking agents on repeated stimulus. Or am i wrong?

  4. Something I don't understand is why a drug like Bethanechol would be selective for Muscarinic receptors. From my understanding, they are resistant to cholinesterase meaning the effects can last longer but why is it M selective if it is binding to a cholinergic receptor?

  5. I got here after hearing a funny story about an incident in USSR back in 1972 which took place at a chemical weapons factory. There was a leak of their "production", so they used antidote – "Safolen021" (which also blocks these receptors in the brain), just in case, as there were not certainty had they been poisoned or not. They were not. At which point this antidote turned out to have a side effect – it induced psychosis. This effect was minor, if subjects were under influence of nerve agent, but much, much stronger, if drug alone was used. XD

  6. two minutes in and I'm already understanding this way better than my notes !! THANK You! so hard to find good youtube videos on educational stuff.


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